| HSV invade the human body mainly through skin, mucous membrane or wounds, and firstly replicate itself in epidermic cells and dermic cells. No matter with or without clinical symptoms, the virus infect the endings of sensory nerve and autonomic nerve. The virus enters into the nerve cells inside ganglion along the neurite. HSV-1 generally is infected through respiratory tract, alimentary tract as well as close contact of skin and mucous membrane. Thus, HSV-1 often incubates on root of trigeminal and inside superior cervical ganglion. That why the clinical symptoms mainly is herpes on face. HSV-2 mainly is transmitted by sexual behaviors and infected through contact of reproductive organs, therefore, HSV-2 often incubates inside sacral ganglia, and that's why it mainly manifests itself as genital herpes in clinic.
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